Division Research

The Division’s faculty has a broad range of research interests. These include hospital epidemiology, diagnostic testing, development and evaluation of innovative culture and nonculture-based systems to detect bloodstream infections; laboratory detection of emerging antimicrobial resistance; improved methods of in vitro susceptibility testing; implementation of systems to optimize the rational use of antimicrobial agents; and clinical trials of innovative antibiotics for multidrug-resistant bacteria.

In addition, the ID and allergy faculty annually mentor medical students, medical residents and ID fellows in numerous quality assurance and other clinical research projects.

Selected Peer-Reviewed Publications from AY 2023-2024

Albin, O. R., Troost, J. P., Saravolatz, L., 2nd, Thomas, M. P., Hyzy, R. C., Konkle, M. A., Weirauch, A. J., Dickson, R. P., Rao, K., & Kaye, K. S. (2024). A quasi-experimental study of a bundled diagnostic stewardship intervention for ventilator-associated pneumonia. Clin Microbiol Infect, 30(4), 499-506. https://doi.org/10.1016/j.cmi.2023.12.023

Bhowmick, T., Abdul Azim, A., Narayanan, N., & Kaye, K. (2023). Traits and skills of effective leaders in antimicrobial stewardship. Antimicrob Steward Healthc Epidemiol, 3(1), e222. https://doi.org/10.1017/ash.2023.499

Dhar, S., Jinadatha, C., Kilgore, P. E., Henig, O., Divine, G. W., Todter, E. N., Coppin, J. D., Carter, M. J., Chopra, T., Egbert, S., Carling, P. C., & Kaye, K. S. (2024). Lowering the Acquisition of Multi-drug Resistant Organism (MDROs) with Pulsed-xenon (LAMP) Study: a cluster randomized controlled, double-blinded, interventional crossover trial. Clin Infect Dis. https://doi.org/10.1093/cid/ciae240

Kaye, K. S., McLeod, S. M., O’Donnell, J. P., & Altarac, D. (2023). Sulbactam-durlobactam for infections caused by Acinetobacter baumannii-calcoaceticus complex – Authors’ reply. Lancet Infect Dis, 23(8), e275-e276. https://doi.org/10.1016/S1473-3099(23)00423-1

Kerai, A., Doshi, S., Laleker, A., & Majumdar, A. (2024). Fungal Foe and Mechanical Hearts: A Retrospective Case Series on Candida auris Bloodstream Infection With Left Ventricular Assist Devices. Open Forum Infect Dis, 11(6), ofae286. https://doi.org/10.1093/ofid/ofae286

Majumdar, A., Shah, M. R., Park, J. J., Narayanan, N., Kaye, K. S., & Bhatt, P. J. (2023). Challenges and Opportunities in Antimicrobial Stewardship among Hematopoietic Stem Cell Transplant and Oncology Patients. Antibiotics (Basel), 12(3). https://doi.org/10.3390/antibiotics12030592

McDonald, E. G., Aggrey, G., Tarik Aslan, A., Casias, M., Cortes-Penfield, N., Dong, M. Q. D., Egbert, S., Footer, B., Isler, B., King, M., Maximos, M., Wuerz, T. C., Azim, A. A., Alza-Arcila, J., Bai, A. D., Blyth, M., Boyles, T., Caceres, J., Clark, D., . . . Lee, T. C. (2023). Guidelines for Diagnosis and Management of Infective Endocarditis in Adults: A WikiGuidelines Group Consensus Statement. JAMA Netw Open, 6(7), e2326366. https://doi.org/10.1001/jamanetworkopen.2023.26366

McLeod, S. M., O’Donnell, J. P., Narayanan, N., Mills, J. P., & Kaye, K. S. (2024). Sulbactam-durlobactam: a beta-lactam/beta-lactamase inhibitor combination targeting Acinetobacter baumannii. Future Microbiol, 19(7), 563-576. https://doi.org/10.2217/fmb-2023-0248

Mohayya, S. M., Arsalan, M., Narayanan, N., Patel, P., Hong, C. G., Kirn, T. J., Bhatt, P. J., & Bhowmick, T. (2023). Impact of phenotypic rapid diagnostic assay on duration of empiric antibiotics for gram-negative bacteremia. Antimicrob Steward Healthc Epidemiol, 3(1), e22. https://doi.org/10.1017/ash.2022.331

Patell, R., Cool, J. A., Merchant, E., Dodge, L. E., Ricotta, D. N., Persaud, B., Gomez, L. K., Yang, L., Trainor, A., Carney, B., William, J., Lecker, S., Theodore, M., Petri, C., Horst, D., Stein, D., Forbath, N., Azim, A., Hale, A. J., & Freed, J. A. (2024). Rethinking the consultation paradigm: Validity evidence for a new framework, a multimethods study. J Hosp Med, 19(4), 259-266. https://doi.org/10.1002/jhm.13312

Pierce, V. M., Bhowmick, T., & Simner, P. J. (2023). Guiding antimicrobial stewardship through thoughtful antimicrobial susceptibility testing and reporting strategies: an updated approach in 2023. J Clin Microbiol, 61(11), e0007422. https://doi.org/10.1128/jcm.00074-22

Rao, K., Zhao, Q., Bell, J., Krishnan, J., Henig, O., Daniel, J., Sawaya, K., Albin, O., Mills, J. P., Petty, L. A., Gregg, K., Kaul, D., Malani, A. N., Pogue, J., & Kaye, K. S. (2024). An Open-Label, Randomized Trial Comparing Fidaxomicin With Oral Vancomycin for the Treatment of Clostridioides difficile Infection in Hospitalized Patients Receiving Concomitant Antibiotics for Concurrent Infections. Clin Infect Dis, 78(2), 277-282. https://doi.org/10.1093/cid/ciad606

Roy, A. S., Hagh-Doust, H., Abdul Azim, A., Caceres, J., Denholm, J. T., Dong, M. Q. D., King, M., Yen, C. F., Lee, T. C., & McDonald, E. G. (2023). Multidisciplinary Teams for the Management of Infective Endocarditis: A Systematic Review and Meta-analysis. Open Forum Infect Dis, 10(9), ofad444. https://doi.org/10.1093/ofid/ofad444

Simon Frances, B., Nair, N., Gaur, A., Plotz, B., & Majumdar, A. (2023). Spectre of COVID-19 infection confounding myocarditis related to cytomegalovirus mononucleosis syndrome and hyperinflammatory syndrome. Heliyon, 9(11), e21383. https://doi.org/10.1016/j.heliyon.2023.e21383

Sui, J., Lin, Z., Azizpour, S., Chen, F., Gaur, S., Keene, K., Soleimani, F., Bhowmick, T., Rafique, Z., & Javanmard, M. (2024). Clinical evaluation of a fully electronic microfluidic white blood cell analyzer. PLoS One, 19(1), e0296344. https://doi.org/10.1371/journal.pone.0296344

Yang, A. F., Sherman, A., Nazarian, E., Haas, W., Mehr, J., Pedrani, M., Kirn, T., Brant, S., Boruchoff, S. E., Kaye, K. S., & Mills, J. P. (2024). Evidence of transmission of New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae through a gastrointestinal endoscope without an elevator channel. Infect Control Hosp Epidemiol, 1-6. https://doi.org/10.1017/ice.2024.55

Yassin, A., Kaye, K. S., & Bhowmick, T. (2024). Unitary Tract Infection Treatment: When to Use What Agents including Beta-lactam Combination Agents. Infect Dis Clin North Am, 38(2), 295-310. https://doi.org/10.1016/j.idc.2024.03.007

Akanmu S, Herrera BB, Chaplin B, Ogunsola S, Osibogun A, Onawoga F, John-Olabode S, Akase IE, Nwosu A, Hamel DJ, Chang CA, Kanki PJ. High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular immune responses. J Clin Virol Plus. 2023 Aug;3(3):100156. https://doi.org/10.1016/j.jcvp.2023.100156

Sena BF, Herrera BB, Bruneska Gondim Martins D, Lima Filho JL. Advancing arbovirus diagnosis in Brazil: strengthening diagnostic strategies and public health data collection. Braz J Infect Dis. 2024 May-Jun;28(3):103766. https://doi.org/10.1016/j.bjid.2024.103766

Joseph J, Sandel G, Kulkarni R, Alatrash R, Herrera BB, Jain P. Antibody and Cell-Based Therapies against Virus-Induced Cancers in the Context of HIV/AIDS. Pathogens. 2023 Dec 22;13(1):14. https://doi.org/10.3390/pathogens13010014

Alatrash R, Herrera BB. The Adaptive Immune Response against Bunyavirales. Viruses. 2024 Mar 21;16(3):483. https://doi.org/10.3390/v16030483

Burdo TH, Chen C, Kaminski R, Sariyer IK, Mancuso P, Donadoni M, Smith MD, Sariyer R, Caocci M, Liao S, Liu H, Huo W, Zhao H, Misamore J, Lewis MG, Simonyan V, Thompson EE, Xu EY, Cradick TJ, Gordon J, Khalili K. Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates. Gene Ther. 2024 May;31(5-6):224-233. https://doi.org/10.1038/s41434-023-00410-4 Epub 2023 Aug 17. Erratum in: Gene Ther. 2024 Jul;31(7-8):434-435. https://doi.org/10.1038/s41434-023-00438-6

Caocci M, Niu M, Fox HS, Burdo TH. HIV Infection Drives Foam Cell Formation via NLRP3 Inflammasome Activation. Int J Mol Sci. 2024 Feb 17;25(4):2367. https://doi.org/10.3390/ijms25042367

Srinivasa S, Walpert AR, Thomas TS, Huck DM, Jerosch-Herold M, Islam S, Lu MT, Burdo TH, deFilippi CR, Dunderdale CN, Feldpausch M, Iyengar S, Shen G, Baak S, Torriani M, Robbins GK, Lee H, Kwong R, DiCarli M, Adler GK, Grinspoon SK. Randomized Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Myocardial Perfusion and Function Among Persons With Human Immunodeficiency Virus (HIV)-Results From the MIRACLE HIV Study. Clin Infect Dis. 2023 Oct 13;77(8):1166-1175. https://doi.org/10.1093/cid/ciad310