Fellows may participate in research projects related to clinical, basic science or both with any of the fulltime faculty members in the division. Clinical trials sponsored by the National Institutes of Health and the pharmaceutical industry are routinely conducted in the division. Current faculty research interests include osteoporosis and other metabolic bone diseases; hyperlipidemia; diabetes and obesity; exercise physiology; and thyroid disorders.
For further information on Research projects going on in our Department go to:
http://rwjms.rutgers.edu/meds-peds
Recent Publications:
Sullivan AM, Beltran CP, Ranchoff BL, Hayes MM, Atkins KM, Tibbles CD, Cohen AP, Cohen DA, Huang GC, Schwartzstein RM; Clinician Educator Research Group. Enhancing Clinical Teaching in Critical Thinking, High-Value Care, and Health Care Equity. J Contin Educ Health Prof. 2022 Jul 1;42(3):164-173. doi: 10.1097/CEH.0000000000000441. PMID: 36007516
Watari J, Vekaria S, Lin Y, Patel M, Kim H, Kang F, Lubitz S, Beninato T, Laird AM. Radiology report language positively influences adrenal incidentaloma guideline adherence. Am J Surg. 2022 Feb;223(2):231-236. doi: 10.1016/j.amjsurg.2021.06.015. Epub 2021 Jun 29. PMID:34243951
Cohen DA, Ricotta DN, Parikh PD. Things we do for no reason™: Routinely holding metformin in the hospital. J Hosp Med. 2022 Mar;17(3):207-210. doi: 10.12788/jhm.3644. PMID: 34424186
Bassin SR, Kohm K, Fitzgerald N, Cohen DA. An Assessment of Nutrition Education in Endocrinology Fellowship Programs in the United States. Endocr Pract. 2022 Mar;28(3):310-314. doi: 10.1016/j.eprac.2021.12.012. Epub 2021 Dec 26. PMID: 34965450
Scherer T, Sakamoto K, Buettner C. Brain insulin signalling in metabolic homeostasis and disease. Nat Rev Endocrinol. 2021 Aug;17(8):468-483. doi: 10.1038/s41574-021-00498-x. Epub 2021 Jun 9. PMID: 34108679
Bassin SR, Amorosa L. Prophylactic Antithyroid Treatment Prior to Contrast Imaging in Hyperthyroid Patients. Endocr Pract. 2021 Jul;27(7):757-759. doi: 10.1016/j.eprac.2021.03.003. Epub 2021 Mar 9. PMID: 3371148
Patel K, Levesque K, Mark V, Pierini E, Rojas B, Ahlers M, Shah A, Laferrère B. Proinsulin associates with poor β-cell function, glucose-dependent insulinotropic peptide, and insulin resistance in persistent type 2 diabetes after Roux-en-Y gastric bypass in humans. J Diabetes. 2020 Jan;12(1):77-86. doi: 10.1111/1753-0407.12964. Epub 2019 Jul 24. PubMed PMID: 31245904; PubMed Central PMCID: PMC6923566.
King RA, Patel KC, Mark VM, Shah A, Laferrère B. Role of Ethnicity on Weight Loss and Attrition After Bariatric Surgery. Obes Surg. 2019 Nov;29(11):3577-3580. doi: 10.1007/s11695-019-04029-6. PubMed PMID: 31201695.
Shah A, Holter MM, Rimawi F, Mark V, Dutia R, McGinty J, Levin B, Laferrère B. Insulin Clearance After Oral and Intravenous Glucose Following Gastric Bypass and Gastric Banding Weight Loss. Diabetes Care. 2019 Feb;42(2):311-317. doi: 10.2337/dc18-1036. Epub 2018 Dec 6. PubMed PMID: 30523032; PubMed Central PMCID: PMC6341286.
X Wang, LQ Meng, C Su, S Trooskin, ZF Sheng, S Shapses. 25-hydroxyvitamin D and Vitamin D Binding Protein Levels in Patients with Primary Hyperparathyroidism Before and after parathyroidectomy Frontiers in Endocrinology, Section of Bone Research, 2019, DOI: 10.3389/fendo.2019.00171
K Sluis, H Kim, Y He, B Wong and X Wang. Therapeutic Challenges for Elderly Patients with Primary Hyperparathyroidism, Case Reports in Endocrinology 2019(1):1-3 DOI: 10.1155/2019/4807081
A Dayyeni, A Mahdi, Y He, L Meng, X Wang Parathyroid Gland Weight Is Associated with High Density Lipoprotein Levels in Patients with Primary Hyperparathyroidism. J Clin Transla Endocrinol. DOI: 10.1016/j.jcte.2019.100213
Wang X, Meng L, Su C, Shapses SA. LOW FREE (BUT NOT TOTAL) 25-HYDROXYVITAMIN D LEVELS IN SUBJECTS WITH NORMOCALCEMIC HYPERPARATHYROIDISM. Endocr Pract. 2020; 26: 174-178 doi: 10.4158/EP-2019-0325
J Zaidan, X Wang: TRANSIENT PRIMARY HYPERPARATHYROIDISM: A RARE FORM OF HYPERPARATHYROIDISM. Endocr Pract 2020: 26(3):357-358. DOI: 10.4158/1934-2403-26.3.357
Xie, Z., Bikle, D. D., Wang, X. Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions January 2020. Frontiers in Endocrinology 11:40 DOI: 10.3389/fendo.2020.00040.
Meng L, Su C, Shapses SA, Al-Dayyeni A, He Y, Wang X. Lower total 25-hydroxyvitamin D but no difference in calculated or measured free 25-hydroxyvitamin D serum levels in patients with primary hyperparathyroidism. J Steroid Biochem Mol Biol. 2020 Feb 3;199:105616. doi: 10.1016/j.jsbmb.2020.105616.
Zhang Z, Yan X, Wu C, Pei X, Li X, Wang X, Niu X, Jiang H, Zeng X, Zhou Z. Adding Vitamin D3 to the Dipeptidyl Peptidase-4 Inhibitor Saxagliptin Has the Potential to Protect β-Cell Function in LADA Patients: A One-Year Pilot Study. Diabetes Metab Res Rev. 2020 Feb 10: e3298. doi: 10.1002/dmrr.3298. [Epub ahead of print]
J Zaidan, X Wang, High-Dose Vitamin D3 for Critically Ill Vitamin D–Deficient Patients. N Engl J Med 2020; 382:1669-1671DOI: 10.1056/NEJMc2000993
J Zaidan, X Wang. Total 25(OH)D level is not a reliable indicator of vitamin D status in normacalcemic PHPT. May 2020, Journal of Clinical Endocrinology & Metabolism DOI: 10.1210/clinem/dgaa275 [Epub ahead of print]
Magdalena Dragan , Mai-Uyen Nguyen , Stephania Guzman , Cameron Goertzen , Muriel Brackstone , Waljit S Dhillo , Paul R Bech , Sophie Clarke , Ali Abbara , Alan B Tuck , David A Hess , Sharon R Pine , Wei-Xing Zong , Frederic E Wondisford , Xiaoyang Su, Andy V Babwah , Moshmi Bhattacharya. G Protein-Coupled Kisspeptin Receptor Induces Metabolic Reprograming and Tumorigenesis in Estrogen Receptor-Negative Breast Cancer. Cell Death Dis. 2020; 11(2):106
Guzman S, Brackstone M, Wondisford F, Babwah AV, Bhattacharya M. KISS1/KISS1R and Breast Cancer: Metastasis Promoter. Semin Reprod Med. 2019; 37(4):197-206. PMID: 31972865
de Oliveira V, Schaefer J, Calder M, Lydon JP, DeMayo FJ, Bhattacharya M, Radovick S, Babwah AV.Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. FASEB J. 2019; 33(8):9374-9387. PMID: 31091422
de Oliveira V, Schaefer J, Abu-Rafea B, Vilos GA, Vilos AG, Bhattacharya M, Radovick S, Babwah AV. Uterine aquaporin expression is dynamically regulated by estradiol and progesterone and ovarian stimulation disrupts embryo implantation without affecting luminal closure. Mol Hum Reprod. 2020; 26(3):154-166. PMID: 31977023
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased β-cell proliferation prior to immune-cell invasion prevents progression of type 1 diabetes. (2019). Nature Metabolism. 5, 509-518.
Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RWS, El Ouaamari A, Teo AK, Bhatt S, Hu J, Kulkarni RN. Human duct cells are a source of β-cell reserve in the compensatory response to insulin resistance. (2019) JCI insight 4(8): e99576.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, et al. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020 Mar 7;31(4):809-821.e6.
Liu J, Zhang C, Wu H, Sun X-X, Li Y, Huang S, et al. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020 May 18;130(6):3253–69.
Su X, Chiles E, Maimouni S, Wondisford FE, Zong W-X, Song C. In-Source CID Ramping and Covariant Ion Analysis of Hydrophilic Interaction Chromatography Metabolomics. Anal Chem. 2020;14:37.
Chen L, Vasoya RP, Toke NH, Parthasarathy A, Luo S, Chiles E, et al. HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice. Gastroenterology. 2020 Mar 1;158(4):985-999.e9.
Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo WS, et al. G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer. Cell Death Dis. 2020;11(2).
Wang Y, Kwon H, Su X, Wondisford FE. Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting. Mol Metab. 2020 Jan 1;31:36–44.
Du D, Tan L, Wang Y, Peng B, Weinstein JN, Wondisford FE, et al. ElemCor: Accurate data analysis and enrichment calculation for high-resolution LC-MS stable isotope labeling experiments. BMC Bioinformatics. 2019;20(1):1–9.
Kalemba KM, Wang Y, Xu H, Chiles E, McMillin SM, Kwon H, et al. Glycerol induces G6pc in primary mouse hepatocytes and is the preferred substrate for gluconeogenesis both in vitro and in vivo. J Biol Chem. 2019 Nov 29;294(48):18017–28.
Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, et al. Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019 Oct 29;29(5):1287-1298.e6.
Dong M, Dando EE, Kotliar I, Su X, Dzikovski B, Freed JH, et al. The asymmetric function of Dph1–Dph2 heterodimer in diphthamide biosynthesis. J Biol Inorg Chem. 2019;24(6):777–82.
Chiles E, Wang Y, Kalemba KM, Kwon H, Wondisford FE, Su X. Fast LC-MS quantitation of glucose and glycerol via enzymatic derivatization. Anal Biochem. 2019;575(March):40–3.
Bhatt V, Khayati K, Hu ZS, Lee A, Kamran W, Su X, et al. Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient kras-driven lung tumorigenesis. Genes Dev. 2019;33(3–4):150–65.
Youn, D.Y., Xiaoli, A.M., Kwon, H., Yang, F. and Pessin, J.E. (2019) “The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity””, J. Biol. Chem. 294, 9076-9083
Chiles, E., Wang, Y., Kalemba, K., Kwon, H., Wondisford, F.E. and Su, X. (2019) “Fast LC-MS Quantitation of Glucose and Glycerol Via Enzymatic Derivatization”, Anal. Biochem. 575, 40-43
Minakhina S., Bansal S., Zhang A., Brotherton M., Janodia R., De Oliveira V., Tadepalli S. & Wondisford F.E. (2020) A Direct Comparison of Thyroid Hormone Receptor Protein Levels in Mice Provides Unexpected Insights into Thyroid Hormone Action. Thyroid.