Research

Major Research Efforts of Faculty:

Drs. Philipp, Rose, Harrison, and Michaels

  • Screening for Bleeding Disorders in women with menorrhagia.
  • Elevated Factor VII as a risk factor for recurrent fetal loss
  • Association of intrauterine growth restriction with maternal and fetal hemostatic risk factors.
  • Role of a hemophilia treatment center in the management of women with menorrhagia.
  • Integration and Prevention Services for persons with bleeding and clotting disorders.
  • Management of Menorrhagia in women with bleeding disorders.
  • Universal Data and Serum Specimen Collection System for Hemophilia.
  • Platelet abnormalities in women with unexplained menorrhagia.
  • Recombinant antihemophilic factor without added human or animal protein: previously treated severe Hemophilia A.
  • Recombinant antihemophilic factor without added human or animal protein: severe Hemophilia A patients undergoing surgery.
  • Epidemiologic study of placental abruption.
  • Age and the Prevalence of Bleeding Disorders in women with menorrhagia.
  • Utility of bleeding time and platelet function analyzer in women with menorrhagia.
  • Open Label Study to Characterize the Safety and Efficacy of BDDrFVIII Manufactured by the Albumin Free Process (ReFacto AF) in the Treatment of Previously Treated Patients (PTP) with Severe Hemophilia A.
  • Open-Label Single Arm, Safety and Efficacy Study of Recombinant Human Factor IX (rFIX; BeneFIX®) in Children Less than 6 years of age with severe Hemophilia B.
  • Open Label, Safety and Efficacy Study of Recombinant Human Factor IX (rFIX; BeneFIX) in previously treated patients (PTPs) with Hemophilia B (FIX: C £ 2%).
  • NovoSeven® (rFVIIa) by Single Dose for Home Treatment of Joint Bleeds in Hemophilia Patients with Inhibitors: A Pilot, Double-Blind Study versus Standard Multiple Doses of Novoseven and Open-Label FEIBA®.

Peer-Reviewed Articles

Philipp CS, Faiz A, Dowling NF, Beckman M, Owens S, Ayers C, Bachmann G.  Development of a screening tool for identifying women with menorrhagia for hemostatic evaluation.  Am J Obstetrics Gynecology, 2008; 198(2):163.e1-8.  PMID: 18226613

Strair RK, Gharibo G, Schaar D, Rubin A, Harrison J, Aisner J, Taber K, Li Shen, Dudek L, Lin H, Lin Y, Goodell L, Rabson A, Medina D.  Nuclear Factor- kappaB modulation in patients with AML undergoing induction chemotherapy for acute myelogenous leukemia Clin Cancer Research 2008 Vol 14(22); 7564-8.  PMID: 19010875

Chen-Deutsch X, Garay E, Zhang J, Harrison JS and George P. Studzinski  c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.  Leukemia Research 2009; 33(10):1298-300.  PMID: 19339050

Kouides P, Byams V, Philipp C, Stein S, Heit J, Lukes A, Skerrette N, Dowling N, Evatt B, Miller C, Owens S, Kulkarni R.  Multisite management study of menorrhagia with abnormal laboratory hemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid.  British Journal of Haematology, 2009, 145(2) 212-220. PMID: 19236375

Rose S, Ali Y, Kumar A, Saidi P.  Deep venous thrombosis caused by congenital interruption of the inferior vena cava and hereditary thrombophilia. Am J Med Sci 2009; 337(1): 67–70.  PMID: 19002010

Abstract Listing

  • Philipp CS, Faiz A, Byams V, Miller CH, Heit JA, Kouides PA, Kulkarni R, Lukes A, Stein SF.  Screening tool for bleeding disorders in women with menorrhagia:  evaluation in a prospective US multi-site cohort.  Blood 2008; 112: 1237 (Presented American Society Hematology, 2008)
  • Heit JA, Beckman M, Grant A, Key NS, Manco-Johnson MJ, Moll S, Bockenstedt P, Kulkarni R, Ortel TL, Philipp CS.  Venous thromboembolism (VTE) characteristics among white- and black-Americans:  a cross sectional study.  Blood 2008; 112: 3831 (Presented American Society Hematology, 2008)
  • Rossova V, Zhang J, Khanin M, Pesakhov S, Shpilberg O, Harrison JS, Levi I, Rouvio 0, Studzinski GP, Danilenko M.  Plant polyphenols potentiate vitamin D-induced differentiation of myeloid leukemia cells: Role of the antioxidant effect and upregulation of VDR and RXR Cancer Research (2009) Presented at the Annual Meeting of the American Society for Cancer Research, April 2009)
  • Vergano S, Wang X, Harrison J.  Large granular lymphocyte leukemia and pure red cell aplasia in a patient with autoimmune polyglandular syndrome type 1.  (Presented at the American Association of Clinical Endocrinology, 2009